The Clinical and Translational Science Institute (CTSI) sponsored the 4th Pitt Innovation Challenge. This year’s challenge was focused on bold solutions in health. CTSI aims to move health-related research projects along the translational spectrum, not just to commercialization. Ideas and solutions did not need to be products ready for commercialization—basic science projects were encouraged to apply. In addition, the program encouraged new connections within the academic community, and among universities and community organizations, to foster an ecosystem of innovation.