Co-PI Alan Russell and Mark Yazer
Title Continuous Red Blood Cell Production (Phase II)
Description A ready supply of safe and effective red blood cells is a critical component in the treatment of battlefield and civilian trauma. Conventional approaches to this challenge center around voluntary donation of whole blood, testing, processing, extended storage, shipping and therapeutic transfusion of blood or fractionated components. Many of the steps in this conventional approach are prone to error, are inefficient, and in some pathologies can be ineffective. We intend to transform this conventional approach by developing methods and systems to produce erythrocytes (and at a future time, other blood components) from readily available and expandable human non-embryonic progenitor cell populations in a safe, effective, robust and limited footprint in vitro manufacturing system.